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Editorial Advisory Board
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IFC
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| Regular Papers |
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Postmenopausal hormone therapy, timing of initiation, APOE and cognitive decline
01 December 2010
Abstract: Associations between postmenopausal hormone therapy (HT) and cognitive decline may depend on apolipoprotein E (APOE) status or timing of initiation. We included 16,514 Nurses' Health Study p...
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Jae H. Kang,
Francine Grodstein
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1129-1137
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Hormone levels and cognitive function in postmenopausal midlife women
Abstract: Gonadal hormones may influence cognitive function. Postmenopausal midlife women in the population-based Melbourne Women's Midlife Health Project cohort were administered a comprehensive batt...
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Joanne Ryan,
Frank Z. Stanczyk,
Lorraine Dennerstein,
Wendy J. Mack,
Margaret S. Clark,
Cassandra Szoeke,
Daniel Kildea,
Victor W. Henderson
et al.
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1138-1147.e2
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Midlife memory improvement predicts preservation of hippocampal volume in old age
15 November 2010
Abstract: This study examines whether midlife change in episodic memory predicts hippocampal volume in old age. From the Seattle Longitudinal Study we retrospectively identified 84 healthy, cognitivel...
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Paul R. Borghesani,
Kurt E. Weaver,
Elizabeth H. Aylward,
Anne L. Richards,
Tara M. Madhyastha,
Ali R. Kahn,
Olivia Liang,
Rachel L. Ellenbogen,
M. Faisal Beg,
K. Warner Schaie,
Sherry L. Willis
et al.
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1148-1155
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Cortical thinning related to periventricular and deep white matter hyperintensities
14 February 2011
Abstract: Previous studies showed that white matter hyperintensities (WMH) are related to cognitive decline in patients with mild cognitive impairment (MCI) or dementia. Moreover, periventricular WMH ...
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Sang Won Seo,
Jong-Min Lee,
Kiho Im,
Jun-Sung Park,
Sook-Hui Kim,
Sung Tae Kim,
Hyun-Jung Ahn,
Juhee Chin,
Hae-Kwan Cheong,
Michael W. Weiner,
Duk L. Na
et al.
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1156-1167.e1
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Age-related changes in the mesial temporal lobe: the parahippocampal white matter region
04 April 2011
Abstract: The perforant pathway originates from cells in the entorhinal cortex and relays sensory information from the neocortex to the hippocampus, a region critical for memory function. Imaging stud...
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Travis R. Stoub,
Carol A. Barnes,
Raj C. Shah,
Glenn T. Stebbins,
Carolyn Ferrari,
Leyla deToledo-Morrell
et al.
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1168-1176
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White matter hyperintensities and impaired choice stepping reaction time in older people
24 January 2011
Abstract: White matter hyperintensities (WMHs) are associated with impaired mobility in older people, but no studies have identified neuropsychological and sensorimotor mediating factors for this asso...
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Jacqueline J. Zheng,
Kim Delbaere,
Jacqueline C.T. Close,
Perminder S. Sachdev,
Wei Wen,
Stephen R. Lord
et al.
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1177-1185
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Head size may modify the impact of white matter lesions on dementia
21 March 2011
Abstract: We aimed to examine whether total intracranial volume (TICV), a marker of premorbid brain size, modified the impact of the apolipoprotein E (apoE) e4 phenotype and ischemic white matter lesi...
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Ingmar Skoog,
Pernille J. Olesen,
Kaj Blennow,
Bo Palmertz,
Sterling C. Johnson,
Erin D. Bigler
et al.
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1186-1193
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Gray matter atrophy rate as a marker of disease progression in AD
16 December 2010
Abstract: Global gray matter (GM) atrophy rates were quantified from magnetic resonance imaging (MRI) over 6- and 12-month intervals in 37 patients with Alzheimer's disease (AD) and 19 controls using:...
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Valerie M. Anderson,
Jonathan M. Schott,
Jonathan W. Bartlett,
Kelvin K. Leung,
David H. Miller,
Nick C. Fox
et al.
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1194-1202
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Prediction of conversion from mild cognitive impairment to Alzheimer's disease dementia based upon biomarkers and neuropsychological test performance
15 December 2010
Abstract: The current study tested the accuracy of primary MRI and cerebrospinal fluid (CSF) biomarker candidates and neuropsychological tests for predicting the conversion from mild cognitive impairm...
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Michael Ewers,
Cathal Walsh,
John Q. Trojanowski,
Leslie M. Shaw,
Ronald C. Petersen,
Clifford R. Jack,
Howard H. Feldman,
Arun L.W. Bokde,
Gene E. Alexander,
Philip Scheltens,
Bruno Vellas,
Bruno Dubois,
Michael Weiner,
Harald Hampel,
North American Alzheimer's Disease Neuroimaging Initiative (ADNI)
et al.
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1203-1214.e2
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Alzheimer's disease markers, hypertension, and gray matter damage in normal elderly
29 April 2011
Abstract: It is not well known whether Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarkers are associated with brain damage in cognitively normal elderly. The combined influence of CSF bioma...
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Lidia Glodzik,
Lisa Mosconi,
Wai Tsui,
Susan de Santi,
Raymond Zinkowski,
Elizabeth Pirraglia,
Kenneth E. Rich,
Pauline McHugh,
Yi Li,
Schantel Williams,
Fahad Ali,
Henrik Zetterberg,
Kaj Blennow,
Pankaj Mehta,
Mony J. de Leon
et al.
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1215-1227
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Neuropathological correlates of volumetric MRI in autopsy-confirmed Lewy body dementia
25 February 2011
Abstract: The objective of this study was to determine the neuropathological correlates of regional medial temporal lobe volume measures on magnetic resonance imaging (MRI) in subjects with Lewy body ...
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Emma J. Burton,
Elizabeta B. Mukaetova-Ladinska,
Robert H. Perry,
Evelyn Jaros,
Robert Barber,
John T. O'Brien
et al.
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1228-1236
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Age and amyloid-related alterations in default network habituation to stimulus repetition
21 February 2011
Abstract: The neural networks supporting encoding of new information are thought to decline with age, although mnemonic techniques such as repetition may enhance performance in older individuals. Accu...
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Patrizia Vannini,
Trey Hedden,
John A. Becker,
Caroline Sullivan,
Deepti Putcha,
Dorene Rentz,
Keith A. Johnson,
Reisa A. Sperling
et al.
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1237-1252
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| Brief Communication |
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CSF tau markers are correlated with hippocampal volume in Alzheimer's disease
14 April 2011
Abstract: Hippocampal atrophy as assessed by magnetic resonance imaging (MRI) and abnormal cerebrospinal fluid (CSF) biomarkers are supportive features for the diagnosis of Alzheimer's disease (AD) an...
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Leonardo C. de Souza,
Marie Chupin,
Foudil Lamari,
Claude Jardel,
Delphine Leclercq,
Olivier Colliot,
Stéphane Lehéricy,
Bruno Dubois,
Marie Sarazin
et al.
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1253-1257
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| Regular Papers |
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Corticosteroids, but not NSAIDs, are associated with less Alzheimer neuropathology
04 April 2011
Abstract: The objective of this study was to test the hypothesis that corticosteroid and nonsteroidal anti-inflammatory drug (NSAID) medications are associated with less global and regional Alzheimer'...
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Michal Schnaider Beeri,
James Schmeidler,
Gerson T. Lesser,
Maria Maroukian,
Rebecca West,
Stephanie Leung,
Michael Wysocki,
Daniel P. Perl,
Dushyant P. Purohit,
Vahram Haroutunian
et al.
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1258-1264
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Volumetric analysis of the substantia innominata in patients with Parkinson's disease according to cognitive status
10 January 2011
Abstract: The cholinergic system arising from the substantia innominata (SI) of the basal forebrain has an important role in the cognitive functions of Parkinson's disease (PD). We performed magnetic ...
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Seo Hee Choi,
Tae Min Jung,
Ji E. Lee,
Seung-Koo Lee,
Young H. Sohn,
Phil Hyu Lee
et al.
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1265-1272
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Combination therapy prevents amyloid-dependent and -independent structural changes
24 January 2011
Abstract: Neuropathological features of Alzheimer's disease (AD) are recapitulated in transgenic mice expressing familial AD-causing mutations, but ectopic transgene overexpression makes it difficult ...
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Gauri Malthankar-Phatak,
Shane Poplawski,
Nikhil Toraskar,
Robert Siman
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1273-1283
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Aging-related changes of neural mechanisms underlying visual-spatial working memory
06 December 2010
Abstract: Capacities of the prefrontal cortex (PFC) such as working memory (WM) are known to decline with increasing age. However, it is unclear which neurofunctional mechanisms may underlie this agin...
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Martina Piefke,
Özgür A. Onur,
Gereon R. Fink
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1284-1297
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Age-related effects on the neural correlates of autobiographical memory retrieval
30 December 2010
Abstract: Older adults recall less episodically rich autobiographical memories (AM), however, the neural basis of this effect is not clear. Using functional MRI, we examined the effects of age during ...
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Peggy L. St. Jacques,
David C. Rubin,
Roberto Cabeza
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1298-1310
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Age affects chunk-based, but not rule-based learning in artificial grammar acquisition
19 November 2010
Abstract: Explicit learning is well known to decline with age, but divergent results have been reported for implicit learning. Here, we assessed the effect of aging on implicit vs. explicit learning w...
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Julia Kürten,
Meinou H. De Vries,
Kristina Kowal,
Pienie Zwitserlood,
Agnes Flöel
et al.
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1311-1317
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Coexistence of narcolepsy and Alzheimer's disease
24 January 2011
Abstract: A recent publication suggested that hypocretin (Hcrt, orexin) may mediate the neuropathological process leading to Alzheimer's disease (AD) and that antagonism of hypocretin receptors decrea...
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T.E. Scammell,
J.K. Matheson,
M. Honda,
T.C. Thannickal,
J.M. Siegel
et al.
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1318-1319
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Nanobody specific for oligomeric beta-amyloid stabilizes nontoxic form
10 November 2010
Abstract: While accumulation and deposition of beta amyloid (Aβ) is a primary pathological feature of Alzheimer's disease (AD), increasing evidence has implicated small, soluble oligomeric aggregates ...
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Srinath Kasturirangan,
Lin Li,
Sharareh Emadi,
Shanta Boddapati,
Philip Schulz,
Michael R. Sierks
et al.
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1320-1328
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Intracellular Aβ-oligomers and early inflammation in a model of Alzheimer's disease
17 March 2011
Abstract: Lifelong use of nonsteroidal anti-inflammatory drugs (NSAIDs) has been shown to diminish the incidence of Alzheimer's disease (AD), suggesting a key role of inflammation in early stages of t...
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Maria Teresa Ferretti,
Martin A. Bruno,
Adriana Ducatenzeiler,
William L. Klein,
A. Claudio Cuello
et al.
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1329-1342
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Neuronal histamine production remains unaltered in Parkinson's disease despite the accumulation of Lewy bodies and Lewy neurites in the tuberomamillary nucleus
03 March 2011
Abstract: Neuronal histamine production in the hypothalamic tuberomamillary nucleus (TMN) was hypothesized to change significantly in Parkinson's disease (PD) in relation to the accumulation of Lewy b...
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Ling Shan,
Chun-Qing Liu,
Rawien Balesar,
Michel A. Hofman,
Ai-Min Bao,
Dick F. Swaab
et al.
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1343-1344
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Assessment of activation of the plasma kallikrein-kinin system in frontal and temporal cortex in Alzheimer's disease and vascular dementia
15 November 2010
Abstract: Decreased cerebral blood flow and blood-brain barrier disruption are features of Alzheimer's disease (AD). The plasma kallikrein-kinin system modulates cerebrovascular tone through release o...
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Emma L. Ashby,
Seth Love,
Patrick G. Kehoe
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1345-1355
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Age dependence of excitatory-inhibitory balance following stroke
24 January 2011
Abstract: The mechanisms which mediate cortical map plasticity and functional recovery following stroke remain a matter of debate. Readjustment of the excitatory-inhibitory balance may support cortica...
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Silvio Schmidt,
Claus Bruehl,
Christiane Frahm,
Christoph Redecker,
Otto W. Witte
et al.
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1356-1363
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The inhalation anesthetic isoflurane increases levels of proinflammatory TNF-α, IL-6, and IL-1β
29 December 2010
Abstract: Anesthetics have been reported to promote Alzheimer's disease (AD) neuropathogenesis by inducing β-amyloid protein accumulation and apoptosis. Neuroinflammation is associated with the emerge...
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Xu Wu,
Yan Lu,
Yuanlin Dong,
Guohua Zhang,
Yiying Zhang,
Zhipeng Xu,
Deborah J. Culley,
Gregory Crosby,
Edward R. Marcantonio,
Rudolph E. Tanzi,
Zhongcong Xie
et al.
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1364-1378
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Perlecan domain V inhibits α2 integrin-mediated amyloid-β neurotoxicity
02 December 2010
Abstract: Amyloid-β (Aβ) peptide is a key component of amyloid plaques, one of the pathological features of Alzheimer's disease. Another feature is pronounced cell loss in the brain leading to an enla...
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Sarah Wright,
Christi Parham,
Boyeon Lee,
Douglas Clarke,
Lisa Auckland,
Jennifer Johnston,
Andrea L. Lawrence,
S. Kent Dickeson,
Samuel A. Santoro,
Irene Griswold-Prenner,
Gregory Bix
et al.
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1379-1388
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Regulation of alternative splicing of tau exon 10 by 9G8 and Dyrk1A
07 January 2011
Abstract: Adult human brain expresses 6 isoforms of tau protein as a result of alternative splicing. Alternative splicing of exon 10 (E10) leads to tau isoforms containing either 3 (3R-tau) or 4 (4R-t...
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Shaohong Ding,
Jianhua Shi,
Wei Qian,
Khalid Iqbal,
Inge Grundke-Iqbal,
Cheng-Xin Gong,
Fei Liu
et al.
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1389-1399
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AGEs induce Alzheimer-like tau pathology and memory deficit via RAGE-mediated GSK-3 activation
31 March 2011
Abstract: Accumulation of β-amyloid and hyperphosphorylated tau with synapse damage and memory deterioration are hallmark lesions of Alzheimer disease (AD), but the upstream causative factors are elus...
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Xiao-Hong Li,
Bing-Ling Lv,
Jia-Zhao Xie,
Jing Liu,
Xin-Wen Zhou,
Jian-Zhi Wang
et al.
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1400-1410
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Interferon-γ plays a role in paraquat-induced neurodegeneration involving oxidative and proinflammatory pathways
13 April 2011
Abstract: Exposure to environmental contaminants, particularly pesticides, may be an important etiological factor in Parkinson's disease (PD); and evidence suggests a role for microglia-dependent infl...
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Emily N. Mangano,
Darcy Litteljohn,
Remmick So,
Eric Nelson,
Sarah Peters,
Cheri Bethune,
Jessica Bobyn,
Shawn Hayley
et al.
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1411-1426
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Ultrastructural alterations of Alzheimer's disease paired helical filaments by grape seed-derived polyphenols
03 January 2011
Abstract: Abnormal folding of the microtubule-associated protein tau leads to aggregation of tau into paired helical filaments (PHFs) and neurofibrillary tangles, the major hallmark of Alzheimer's dis...
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Hanna Ksiezak-Reding,
Lap Ho,
Ismael Santa-Maria,
Carmen Diaz-Ruiz,
Jun Wang,
Giulio Maria Pasinetti
et al.
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1427-1439
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Weak BMAA toxicity compares with that of the dietary supplement beta-alanine
14 January 2011
Abstract: Beta-N-methylamino-l-alanine (BMAA) is routinely described in the literature as a potent neurotoxin and as a possible cause of neurodegenerative disorders of aging such as Alzheimer's diseas...
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Moonhee Lee,
Patrick L. McGeer
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1440-1447
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First transgenic rat model developing progressive cortical neurofibrillary tangles
03 January 2011
Abstract: Neurofibrillary degeneration induced by misfolded protein tau is considered to be one of the key pathological hallmarks of Alzheimer's disease (AD). In the present study, we have introduced ...
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Peter Filipcik,
Norbert Zilka,
Ondrej Bugos,
Juraj Kucerak,
Peter Koson,
Petr Novak,
Michal Novak
et al.
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1448-1456
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In vivo molecular imaging of the GABA/benzodiazepine receptor complex in the aged rat brain
27 January 2011
Abstract: The GABA-ergic system, known to regulate neural tissue genesis during cortical development, has been postulated to play a role in cerebral aging processes. Using in vivo molecular imaging an...
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Elseline Hoekzema,
Santiago Rojas,
Raúl Herance,
Deborah Pareto,
Sergio Abad,
Xavier Jiménez,
Francisca P. Figueiras,
Foteini Popota,
Alba Ruiz,
Núria Flotats,
Francisco J. Fernández,
Milagros Rocha,
Mariana Rovira,
Víctor M. Víctor,
Juan D. Gispert
et al.
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1457-1465
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Correlation of cognitive performance and morphological changes in neocortical pyramidal neurons in aging
16 December 2010
Abstract: It is well established that the cerebral cortex undergoes extensive remodeling in aging. In this study, we used behaviorally characterized rats to correlate age-related morphological changes...
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Simon Allard,
Tina Scardochio,
A. Claudio Cuello,
Alfredo Ribeiro-da-Silva
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1466-1480
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| Abstracts of Online Articles |
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Aberrant heart rate and brainstem brain-derived neurotrophic factor (BDNF) signaling in a mouse model of Huntington's disease
04 January 2012
Abstract: Huntington's disease (HD) is associated with profound autonomic dysfunction including dysregulation of cardiovascular control often preceding cognitive or motor symptoms. Brain-derived neuro...
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Kathleen J. Griffioen,
Ruiqian Wan,
Tashalee R. Brown,
Eitan Okun,
Simonetta Camandola,
Mohamed R. Mughal,
Terry M. Phillips,
Mark P. Mattson
et al.
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1481.e1-1481.e5
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Genetic testing in familial and young-onset Alzheimer's disease: mutation spectrum in a Serbian cohort
06 January 2012
Abstract: Alzheimer's disease (AD) is the most common form of dementia. To date, more than 200 mutations in three genes have been identified as cause of early-onset autosomal dominant inherited AD. Th...
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Valerija Dobricic,
Elka Stefanova,
Milena Jankovic,
Nicole Gurunlian,
Ivana Novakovic,
John Hardy,
Vladimir Kostic,
Rita Guerreiro
et al.
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1481.e7-1481.e12
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Age-dependent disruption in hippocampal theta oscillation in amyloid-β overproducing transgenic mice
09 January 2012
Abstract: Transgenic mice are used to model increased brain amyloid-β (Aβ) and amyloid plaque formation reflecting Alzheimer's disease pathology. In our study hippocampal network oscillations, populat...
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Liam Scott,
Jianlin Feng,
Tamás Kiss,
Elie Needle,
Kevin Atchison,
Thomas T. Kawabe,
Anthony J. Milici,
Éva Hajós-Korcsok,
David Riddell,
Mihály Hajós
et al.
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1481.e13-1481.e23
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S-adenosylmethionine reduces the progress of the Alzheimer-like features induced by B-vitamin deficiency in mice
06 January 2012
Abstract: Methylation reactions linked to homocysteine in the one-carbon metabolism are increasingly elicited in Alzheimer's disease, although the association of hyperhomocysteinemia and of low B vita...
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Andrea Fuso,
Vincenzina Nicolia,
Laura Ricceri,
Rosaria A. Cavallaro,
Elisa Isopi,
Franco Mangia,
Maria Teresa Fiorenza,
Sigfrido Scarpa
et al.
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1482.e1-1482.e16
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Effects of omega-3 fatty acids on cognitive performance: a meta-analysis
06 February 2012
Abstract: Background: Higher intake of omega-3 fatty acids (n-3 FAs) is associated with a reduced risk of Alzheimer's disease (AD) and milder forms of cognitive impairment (e.g. cognitive impairment n...
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Graham Mazereeuw,
Krista L. Lanctôt,
Sarah A. Chau,
Walter Swardfager,
Nathan Herrmann
et al.
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1482.e17-1482.e29
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Musical experience offsets age-related delays in neural timing
09 January 2012
Abstract: Aging disrupts neural timing, reducing the nervous system's ability to precisely encode sound. Given that the neural representation of temporal features is strengthened with musical training...
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Alexandra Parbery-Clark,
Samira Anderson,
Emily Hittner,
Nina Kraus
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1483.e1-1483.e4
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Behavioral decay in aging male C. elegans correlates with increased cell excitability
30 January 2012
Abstract: Deteriorative changes in behavioral functions are natural processes that accompany aging. In advanced aged C. elegans nematodes, gross decline in general behaviors, such as locomotion and fe...
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Xiaoyan Guo,
Andrew Navetta,
Daisy G. Gualberto,
L. Rene García
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1483.e5-1483.e23
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Nuclear localization of Klotho in brain: an anti-aging protein
16 January 2012
Abstract: Klotho is a putative age-suppressing gene whose overexpression in mice results in extension of life span. The Klotho gene encodes a single-pass transmembrane protein whose extracellular doma...
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Dwight C. German,
Ida Khobahy,
Johanne Pastor,
Makoto Kuro-o,
Xinran Liu
et al.
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1483.e25-1483.e30
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Age-related differences in corticospinal excitability and inhibition during coordination of upper and lower limbs
19 January 2012
Abstract: The ability to coordinate upper and lower limbs—a prerequisite for many everyday activities—is known to decline with age. Here we report 2 experiments in which transcranial magnetic stimulat...
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Hakuei Fujiyama,
Mark R. Hinder,
Matthew W. Schmidt,
Michael I. Garry,
Jeffery J. Summers
et al.
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1484.e1-1484.e14
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Hormetic effect of amyloid-beta peptide in synaptic plasticity and memory
27 January 2012
Abstract: One of the hot topics in Alzheimer's disease research field is the “amyloid hypothesis” postulating that the increase and deposition of beta-amyloid peptides (Aβ) is the main pathogenetic fa...
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Daniela Puzzo,
Lucia Privitera,
Agostino Palmeri
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1484.e15-1484.e24
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| Genetic Reports Abstracts |
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The Alzheimer's associated 5′ region of the SORL1 gene cis regulates SORL1 transcripts expression
24 December 2010
Abstract: SORL1 has been identified as a major contributor to late onset Alzheimer's disease (LOAD). We test whether genetic variability in the 5′ of SORL1 gene modulates the risk to develop LOAD via ...
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Jeanette J. McCarthy,
Sunita Saith,
Colton Linnertz,
James R. Burke,
Christine M. Hulette,
Kathleen A. Welsh-Bohmer,
Ornit Chiba-Falek
et al.
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1485.e1-1485.e8
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Role of tau kinases (CDK5R1 and GSK3B) in Parkinson's disease: A study from India
06 December 2010
Abstract: Glycogen synthase kinase-3β (GSK3B) and cyclin-dependent kinase 5 (CDK5) are the 2 major protein kinases involved in abnormal phosphorylation of tau. To determine their potential role in the...
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Gautami Das,
Amar K. Misra,
Shyamal K. Das,
Kunal Ray,
Jharna Ray
et al.
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1485.e9-1485.e15
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Cognitive phenotypes in Alzheimer's disease and genetic variants in ACE and IDE
13 January 2011
Abstract: Alzheimer's disease (AD) is generally considered to be a disorder primarily affecting memory. It is increasingly recognized that the clinical presentation or “cognitive phenotype” is variabl...
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Emma R.L.C. Vardy,
Kristelle Brown,
Cheryl L. Stopford,
Jennifer C. Thompson,
Anna M. Richardson,
David Neary,
Noor Kalsheker,
Kevin Morgan,
David M. Mann,
Julie S. Snowden
et al.
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1486.e1-1486.e2
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Telomere length and aging biomarkers in 70-year-olds: the Lothian Birth Cohort 1936
03 January 2011
Abstract: Telomeres are nucleo-protein complexes at the end of eukaryotic chromosomes. They shorten each time a somatic cell replicates and this shortening is modulated by the effects of oxidative str...
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Sarah E. Harris,
Carmen Martin-Ruiz,
Thomas von Zglinicki,
John M. Starr,
Ian J. Deary
et al.
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1486.e3-1486.e8
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Using CSF biomarkers to replicate genetic associations in Alzheimer's disease
04 April 2011
Abstract: Defining cases and controls on the basis of biomarkers rather than clinical diagnosis may reduce sample sizes required for genetic studies. The aim of this study was to assess whether charac...
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Jonathan M. Schott,
ADNI Investigators
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1486.e9-1486.e15
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Perimenopausal regulation of steroidogenesis in the nonhuman primate
20 June 2011
Abstract: Human aging is characterized by a marked decrease in circulating levels of dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS), hormonal changes associated with cognitive decline. Despite...
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Krystina G. Sorwell,
Steven G. Kohama,
Henryk F. Urbanski
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1487.e1-1487.e13
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C1824T mutation in the LMNA gene has no association with senile cataract
14 November 2011
Abstract: Mutations in the LMNA gene encoding lamins A/C are responsible for Hutchinson-Gilford syndrome (HGS), a disorder of premature aging. Cataract is 1 of the main manifestations. The most preval...
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Tamilla Sadikov,
Amos J. Simon,
Bat-Chen R. Avraham-Lubin,
Olga Dratviman-Storobinsky,
Yoram Cohen,
Nitza Goldenberg-Cohen
et al.
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1487.e15-1487.e19
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Genome-wide study links MTMR7 gene to variant Creutzfeldt-Jakob risk
05 December 2011
Abstract: The aim of our study was to discover genomic variations related to variant Creutzfeldt-Jakob disease (vCJD) susceptibility. A genome-wide association analysis with most vCJD samples availabl...
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Pascual Sanchez-Juan,
Matthew T. Bishop,
Yurii S. Aulchenko,
Jean-Philippe Brandel,
Fernando Rivadeneira,
Maksim Struchalin,
Jean-Charles Lambert,
Philippe Amouyel,
Onofre Combarros,
Jesus Sainz,
Angel Carracedo,
Andre G. Uitterlinden,
Albert Hofman,
Inga Zerr,
Hans A. Kretzschmar,
Jean-Louis Laplanche,
Richard S.G. Knight,
Robert G. Will,
Cornelia M. van Duijn
et al.
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1487.e21-1487.e28
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Alterations in the histaminergic system in the substantia nigra and striatum of Parkinson's patients: a postmortem study
28 November 2011
Abstract: Earlier studies showed neuronal histamine production in the hypothalamic tuberomamillary nucleus to be unchanged in Parkinson's disease (PD), whereas the histamine levels and innervation in ...
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Ling Shan,
Koen Bossers,
Sabina Luchetti,
Rawien Balesar,
Natasha Lethbridge,
Paul L. Chazot,
Ai-Min Bao,
Dick F. Swaab
et al.
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1488.e1-1488.e13
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Mutation analysis of VCP in familial and sporadic amyotrophic lateral sclerosis
26 December 2011
Abstract: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the progressive loss of motor neurons in the motor cortex, brain stem and spinal cord. Mutations in...
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Kelly L. Williams,
Jennifer A. Solski,
Garth A. Nicholson,
Ian P. Blair
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1488.e15-1488.e16
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Body mass index is associated with biological CSF markers of core brain pathology in Alzheimer's disease
16 January 2012
demonstrate an association between lower body mass index (BMI) and positive Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarkers in a cohort comprising individuals with AD, minimal cognitive...
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Ali Jawaid,
Henning Leske,
Manuela Neumann
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e1-e2
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A potential impact of chronic Helicobacter pylori infection on Alzheimer's disease pathobiology and course
10 February 2012
In their case-control series, Roubaud-Baudron et al. concluded that Alzheimer's disease (AD) patients infected by Helicobacter pylori (Hp) tended to be more cognitively impaired, though studies are ne...
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Jannis Kountouras,
Marina Boziki,
Christos Zavos,
Emmanuel Gavalas,
Evangelia Giartza-Taxidou,
Ioannis Venizelos,
Georgia Deretzi,
Nikolaos Grigoriadis,
Elena Tsiaousi,
Elizabeth Vardaka
et al.
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e3-e4
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Contents
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1489-1491
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Contents
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OBC
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